ReDeeM: single-cell Regulatory multi-omics with Deep Mitochondrial mutation profiling. ReDeeM is an engineering-free single cell sequencing technology for somatic mutation-based retrospective lineage tracing, clonal/subclonal mapping, with simultaneous cell-state profiling (transcriptomics and chromatin accessibility).
The redeemR is the second component in ReDeeM computational toolsets - redeemV is an in-house python package for mapping and deep mitochondrial mutation calling. (Input from rawdata) - redeemR is an in-house R package for downstream lineage tracing and single cell integrative analysis. (Input from redeemV)
The goal of redeemR is to refine the somatic mitochondiral mutations, build the single-cell phylogenetic tree and facilitate clonal/subclonal-resolved single-cell multiomics analysis.
Installation
You can install the development version of redeemR:
devtools::install_github("chenweng1991/redeemR")
library(redeemR)